Businessmen make the decisions. When a young bachelor degreed lab tech enters the lab it is at the direction of his/her managers. They get orders from the board. Cure small cell lung cancer. Treat Alzheimer's by making an antibody to a specific region of amyloid beta.
The combination of business decisions, based on market valuation of certain diseases, along with science decisions directed at accomplishing business decisions has led to many a failed drug development program. In the following clip John Cleese describes this problem (towards the end of the clip). Business folk are too dumb to know how dumb they are. But it's not that they are dumb in business. They lack the scientific understanding needed to discover new avenues that are needed now that we've picked all of the low hanging fruit.
And from now on, read everything I write with an English accent. It just sounds better.
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