We'll Do It Anyway

Science 9 July 2004:Vol. 305. no. 5681, pp. 158 - 159DOI: 10.1126/science.305.5681.158

News of the Week

OBESITY RESEARCH:Labs Fail to Reproduce Protein's Appetite-Suppressing Effects

by Trisha Gura

"In an unusual joint letter in Nature this week, more than 40 scientists announced that they cannot reproduce the central findings of a 2002 Nature paper that showed that a molecule called peptide YY3-36, when injected into rodents, dampens appetite for 12 hours or more."

AFX News: March 2, 2006

"...the Bothell, Wash.-based company said Merck terminated its agreement with XXXXX on March 1 after determining that earlier clinical data had shown PYY3-36 wasn't effective.

Regardless of Merck's decision, XXXXXX said it intends to pursue development of PYY3-36"

August 14, 2006

"XXXX announced today the initiation of a dose ranging study designed to evaluate the pharmacokinetic parameters, appetite, food intake and safety of various doses of XXXXXs proprietary PYY(3-36) nasal spray in obese subjects."


Here we go!!! Get ready for another study!!!

Aug. 14, 2006 PRNewswire-FirstCall/ XXXXX announced today the initiation of a dose ranging study designed to evaluate the pharmacokinetic parameters, appetite, food intake and safety of various doses of XXXXX's proprietary PYY(3-36) nasal spray in obese subjects

By the way, if it works 2 out of 20 studies, does it count? Since the FDA is not a close follower of the ways of science, they will allow it. The question is how well it will work this time and if it doesn't, what will comapany XXXX do? Remember, the decision to continue on with PYY was listed as number 4 on "The Five Dumbest Things on Wall Street This Week" by Colin Barr back in March of this year, 2006. We here at the Cargo Cult Scientist will stick it out to the bitter end. We will never give up until the airplanes either land or the cult gives up it's latest ceremony.